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treatment-plans
Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties. Supports general medical treatment, rehabilitation therapy, mental health care, chronic disease management, perioperative care, and pain management. Includes SMART goal frameworks, evidence-based interventions with minimal text citations, regulator…
tmb-msi-calculator
Tumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkers
tooluniverse-immunotherapy-response-prediction
Predict patient response to immune checkpoint inhibitors (ICIs) by integrating tumor mutational burden (TMB), microsatellite instability (MSI), PD-L1 expression, HLA status, and immune-related gene expression. Outputs ICI Response Score with drug-specific recommendations and resistance-risk assessment. Use for melanoma/NSCLC/RCC immunotherapy decision suppo…
tooluniverse-drug-mechanism-research
Trace drug mechanism of action — primary target → downstream signaling → pathway perturbation → tissue/organ effect → clinical outcome. Uses DrugBank, ChEMBL, KEGG, Reactome, STRING. Use for understanding how a drug works, identifying off-target effects, mechanism-based combination therapy design, and writing mechanism sections of reports.
tooluniverse-hla-immunogenomics
HLA gene-family analysis and MHC-peptide binding for transplant compatibility, vaccine epitope coverage, and cancer immunotherapy. Uses IMGT (HLA polymorphism), IEDB (epitope-MHC binding), UniProt (annotation), DGIdb (druggability). Use for HLA typing/imputation review, vaccine HLA coverage, and immunotherapy prediction biomarkers (HLA-LOH, neoantigen prese…
tooluniverse-immune-repertoire-analysis
TCR/BCR repertoire analysis — V(D)J segment usage, CDR3 sequence diversity, clonality scoring, antigen specificity matching to IEDB, public-clone identification. Use for adaptive immune response characterization, post-treatment immune monitoring, antigen-specific clone tracking, and clonal-expansion analysis in immunotherapy or vaccination studies.
tooluniverse-immunotherapy-response-prediction
Predict patient response to immune checkpoint inhibitors (ICIs) by integrating tumor mutational burden (TMB), microsatellite instability (MSI), PD-L1 expression, HLA status, and immune-related gene expression. Outputs ICI Response Score with drug-specific recommendations and resistance-risk assessment. Use for melanoma/NSCLC/RCC immunotherapy decision suppo…
tooluniverse-drug-mechanism-research
Trace drug mechanism of action — primary target → downstream signaling → pathway perturbation → tissue/organ effect → clinical outcome. Uses DrugBank, ChEMBL, KEGG, Reactome, STRING. Use for understanding how a drug works, identifying off-target effects, mechanism-based combination therapy design, and writing mechanism sections of reports.
tooluniverse-hla-immunogenomics
HLA gene-family analysis and MHC-peptide binding for transplant compatibility, vaccine epitope coverage, and cancer immunotherapy. Uses IMGT (HLA polymorphism), IEDB (epitope-MHC binding), UniProt (annotation), DGIdb (druggability). Use for HLA typing/imputation review, vaccine HLA coverage, and immunotherapy prediction biomarkers (HLA-LOH, neoantigen prese…
tooluniverse-immune-repertoire-analysis
TCR/BCR repertoire analysis — V(D)J segment usage, CDR3 sequence diversity, clonality scoring, antigen specificity matching to IEDB, public-clone identification. Use for adaptive immune response characterization, post-treatment immune monitoring, antigen-specific clone tracking, and clonal-expansion analysis in immunotherapy or vaccination studies.
tooluniverse-immunotherapy-response-prediction
Predict patient response to immune checkpoint inhibitors (ICIs) by integrating tumor mutational burden (TMB), microsatellite instability (MSI), PD-L1 expression, HLA status, and immune-related gene expression. Outputs ICI Response Score with drug-specific recommendations and resistance-risk assessment. Use for melanoma/NSCLC/RCC immunotherapy decision suppo…
pa-clinical-policy
Reasoning skill for prior authorization clinical policy evaluation. Use when the user asks about payer clinical criteria, step therapy requirements, medical necessity definitions, CMS LCD/NCD coverage rules, appeals documentation strategy, formulary tier implications, or FHIR Da Vinci PAS implementation guidance. Triggers include "prior auth policy", "step …
direct-response-copy-therapy
Write CRPO-compliant therapy copy that connects and converts without pressure tactics. Use when writing service pages, CTAs, hero sections, or any persuasive therapy content. Takes core direct-response principles and applies them to therapy context with 40% tone reduction. NO outcome guarantees, NO urgency tactics, NO testimonials. Maintains empathetic, pro…
email-welcome-sequence-therapy
Create CRPO-compliant welcome email sequences for therapy practices that build trust and reduce no-show rates. Use when new leads fill out contact form but before first appointment. Creates 5-7 email nurture sequence that educates, builds connection, and gently encourages booking. Triggers on: create welcome sequence, nurture new leads, reduce no-shows, war…
rehab-scheduling
Audit a rehabilitation scheduling system -- evaluate therapist productivity and utilization rates, PTA/COTA supervision compliance, patient flow and no-show management, equipment and treatment room allocation, insurance authorization tracking with expiration alerts, CMS therapy cap monitoring (KX modifier thresholds), payer-specific visit limits, session fr…
rehab-therapy
Audit a rehabilitation or physical therapy platform end-to-end -- evaluate recovery metrics tracking (ROM, strength, balance, gait), patient-reported outcomes (DASH, LEFS, NDI, ODI, PROMIS), home exercise program personalization and compliance tracking, setback prediction with risk stratification and plateau detection, therapist scheduling and caseload bala…
therapist-documentation
Audit therapy and behavioral health documentation platforms for clinical quality and regulatory compliance. Reviews SOAP, DAP, and BIRP note template structure, note completeness enforcement and timeliness deadlines, note locking and amendment/addendum workflows, DSM-5 diagnostic code completeness, ICD-10-CM crosswalk accuracy and annual update currency, di…
therapy-outcomes
Evaluate therapy outcome measurement systems for rehabilitation and physical therapy. Analyzes functional improvement scoring (MCID, MDC, risk-adjusted residuals), treatment effectiveness comparison by therapist, diagnosis, and facility with case-mix adjustment, discharge readiness prediction (plateau detection, visit utilization trending), patient satisfac…
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