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65 Skillsmixture

bio-clinical-biostatistics-bayesian-trials

bio-clinical-biostatistics-bayesian-trials

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers…

Design und KreativitätSKILL.mdVollständiges ZIP

bio-comparative-genomics-introgression-detection

bio-comparative-genomics-introgression-detection

Detect introgression and admixture between species or populations using Dsuite (Malinsky 2021 fast D-statistics), Patterson's D / ABBA-BABA test (Green 2010; Durand 2011), f4-ratio and f-branch statistic (Malinsky 2018), TreeMix (Pickrell & Pritchard 2012), HyDe (Blischak 2018), QuIBL (Edelman 2019), sprime (Browning 2018), Twisst (Martin 2017), PhyloNet (T…

EntwicklungSKILL.mdVollständiges ZIP

bio-imaging-mass-cytometry-quality-metrics

bio-imaging-mass-cytometry-quality-metrics

Quality control for IMC/MIBI data across pixel, channel, image, slide, and batch levels, covering Poisson-count SNR (cell-level Gaussian-mixture and empty-channel comparison), spillover-matrix QC (the three physical sources), drift and the missing EQ-bead analog, acquisition artifacts, and sample-of-origin batch effects. Use when deciding whether to keep or…

Daten und ForschungSKILL.mdVollständiges ZIP

bio-spatial-transcriptomics-high-resolution-binning

bio-spatial-transcriptomics-high-resolution-binning

Reconstructs single cells from sub-cellular spatial capture units (Visium HD 2um bins, Stereo-seq DNB spots, Slide-seqV2 beads) by aggregating bins UP into cells rather than deconvolving a mixture DOWN. Use when choosing a bin size and recognizing the sparsity-vs-mixture dilemma (2um bins are too sparse to cluster, but binning to 8/16um re-creates the multi…

ProduktivitätSKILL.mdVollständiges ZIP

bio-spatial-transcriptomics-spatial-deconvolution

bio-spatial-transcriptomics-spatial-deconvolution

Estimates per-spot cell type composition of spatial transcriptomics mixtures (Visium, Slide-seq, Stereo-seq) from an scRNA-seq reference with cell2location, RCTD, SPOTlight, stereoscope, SpatialDWLS, or reference-free STdeconvolve. Use when deciding whether a platform even needs deconvolution (the resolution fork -- a 55um Visium spot is a 1-10-cell MIXTURE…

EntwicklungSKILL.mdVollständiges ZIP

ai-hive-gap-068-moe-routing

ai-hive-gap-068-moe-routing

当用户搜索或需要MoE,稀疏模型,Mixture of Experts,模型路由时使用。帮助开发者、AI产品经理、技术负责人、模型采购和成本管理团队完成理解MoE模型的有效参数、速度和成本差异并设计路由,通过AI-HIVE MCP实时核验模型并交付概念说明、任务评测、模型候选、成本表和路由规则。不适用于超出以下边界的请求:不得仅按总参数量判断质量与费用。

EntwicklungSKILL.mdVollständiges ZIP
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